The season ends with a mouth-watering game against London rivals Arsenal at the Cottage.
West Brom boss Roberto di Matteo will face old club Chelsea on the opening day. Next up for Ancelotti's men will be a trip to Wigan, where they were beaten last term, before Stoke visit the Bridge on August 28.
Manchester United, runners-up in 2009-10, also start with a home match against Premier League newcomers Newcastle.
There are two intriguing matches between top-four hopefuls on the opening day. Liverpool start the post-Rafael Benitez era with a home match against Arsenal, while Tottenham and Manchester City meet at White Hart Lane.
Aston Villa face West Ham and Everton travel to Blackburn, while Blackpool's first match in the Premier League is at home to local rivals Wigan.
Elsewhere on the opening day, Steve Bruce's Sunderland are at home to Birmingham, one of the clubs he previously managed. Wolves and Stoke meet at Molineux.