Zamora is set to be out for at least four months after suffering the damage to his right leg during a hard challenge from Wolves skipper Karl Henry. Wolves were shown six yellow cards and one red - Christophe Berra was sent off in injury time for a second bookable offence - but Hughes defended Mick McCarthy's side.
"Wolves were competitive as you'd expect. Mick McCarthy sets his teams up to compete for every ball," he said.
"The Premier League is competitive and I've had similar criticism in the past. Sometimes it's warranted and sometimes it isn't.
"Maybe some of the fouls were made to break up our momentum and maybe at times were a little bit cynical. That's why the crowd was getting frustrated.
"I'd never criticise any team for trying to be competitive against us - that's part and parcel of the Premier League.2
New signing Mousa Dembele hit both of Fulham's goals, the second coming from the injury-time free-kick won when Berra was sent off.
"Mousa was excellent again and is an exciting player. When he's in possession you expect something positive to happen," said Hughes
"There aren't that many players in the Premier League who have that ability. At times it felt like things were going against us - losing Bobby and we had two stonewall penalties turned down.
"When those things conspire against you, you believe that you won't get what you deserve but we were rewarded in the end."