It is 11 months since Fulham boss Hughes was sacked as manager of City when he did not deliver the points quota demanded by the current owners.
City were in sixth place in the Premier League then. Now, under Roberto Mancini, they are fourth but still struggling to make a consistent impact.
And while Hughes insists he has moved on since leaving Eastlands, he said: "Whenever a player goes up against a team he was employed by, or a manager in my circumstances, there is always an extra incentive to try to win the game. I'm no different from any individual in similar circumstances.
"My aim first and foremost is to win for Fulham. It is always nice to go up against former clubs and show that there is life after you have left them."