Fulham have never beaten league leaders Chelsea in the Premier League at Stamford Bridge and their last victory there against their closest London rivals came in 1979.
But Hughes, who spent three years at Stamford Bridge as a player, said: "You have to be positive. Too many teams go to the likes of Stamford Bridge and Old Trafford and they are beaten before they go on the pitch. That is not the attitude or the mentality that I want from my team.
"I had a great three years there (at Stamford Bridge). I left Manchester United and everybody would say you were on the way down and that was the end of your career.
"But I went to the right club and was able to win three trophies in three years. The club had started to move in the right direction. I played a small part in where they are today and I am proud of that."