Pantsil is convinced Hughes, who will be officially unveiled by the club today, can build on everything Roy Hodgson achieved at Craven Cottage before leaving for Liverpool.
Against remarkable odds, Hodgson guided Fulham from the brink of relegation to the Europa League final in the space of two and a half seasons.
Hughes, the former Wales, Blackburn and Manchester City manager, has now taken over the reins and Pantsil is convinced Fulham will only go from strength to strength.
"I have said many times that Roy Hodgson was someone that made me the player that I am today, and for that I am very grateful. But we have to move on - this is what happens in football," said Pantsil.
"The appointment of Mark Hughes is a very exciting one, and I'm looking forward to seeing how this team evolves under his guidance.
"He's a very good manager and I think most of the players have come up against his teams in the past and from those experiences we know that he has a lot of quality. He's someone that commands a lot of respect and is tactically very astute. This will be my third season as a Fulham player and I'm very excited about what could unfold. It will be a challenge, but for me I would love to see the club push as close as they can for a top six finish."