Record £6million signing Charles N'Zogbia was on debut for Wigan and also included in the starting line-up was Colombian Hugo Rodallega, with Amr Zaki on the bench.
The Latics were also boosted by the return of Antonio Valencia.
Still hunting that elusive first away win of the season, Fulham were missing Chris Baird and had loan signing Olivier Dacourt on the bench, but there was no place for their other new arrival Giles Barnes.
Wigan had an early let off when Andy Johnson stumbled over in the box after contact with Paul Scharner but ref Lee Probert was unimpressed by the claims for a penalty.
The ex-Everton striker then fashioned a shooting chance for himself after giving Titus Bramble the slip but Chris Kirkland was
perfectly positioned to block.
Johnson then set up the strike for Bobby Zamora but the Latics keeper did well to tip it away for a corner.
A header from Rodallega was Wigan's only reply early on and they suffered a double blow when Michael Brown and Valencia had to be replaced with only 20 minutes gone.
Mido, who became the third Wigan player to limp off just before the break, injected some life into the proceedings with a stinging shot which was well saved by Mark Schwarzer at the foot of the post and the Egypt striker was desperately unlucky steering a header just wide from Manor Figueroa's cross.
A Simon Davies corner spelled trouble for the Latics after Kirkland missed it, but Zamora headed over from five yards.
Jason Koumas had the chance to break the deadlock but blasted wide and Ben Watson also failed to hit the target
Johnson was a real threat for Fulham and Kirkland had to move quickly to deny him a chance to shoot as the second half opened up and then fizzled out.